CBT, cannabicitran, idadzipatula koyamba kumapeto kwa zaka za m'ma 60s, koyambirira kwa 70s ndipo imapezeka kwambiri mu hemp kuposa chamba. CBT ndi imodzi mwazinthu zodabwitsa kwambiri za cannabinoids ndipo zimawoneka zotsika kwambiri.
- Zimalepheretsa crystalization
- Kuthekera kuchepetsa zotsatira za THC
- Zovuta ndi zochepetsera zowawa
- Zotsatira zina zofanana ndi CBD & CBG
Pakadali pano pakufufuza za CBT, sizothandiza kuyerekeza CBT ndi CBD. Komabe, apa pali kufotokozedwa mwachidule kwa CBT ndi CBD kufanana ndi kusiyana:
- Onsewa sali pyschoactive
- Zonsezi zitha kufooketsa zotsatira za psychoactive za THC
- CBD cannabinoid imawala
- CBT imatha kuletsa mafuta a vape a CBD kuti asawonekere
Ngakhale kafukufuku wochepa pa CBT, wasonyeza kuthekera kopindulitsa mu maphunziro angapo. Ubwino wina wa CBT ndi:
- Kuthekera kusokoneza THC mu dongosolo ndikuchepetsa kuledzera
- Zotheka kupereka thanzi la maso
- Kuthekera kuchepetsa kupsinjika
- Kuthekera kulimbikitsa bwino m'thupi
Ayi, CBT ndi cannabinoid yosaledzeretsa ndipo mawonekedwe amodzi, CBT-C, adawonetsedwa kuti atha kuchepetsa zotsatira zoyipa za THC.
CBT yasonyeza kuthekera kwake pothandiza anthu kusiya kusuta kapena kuchepetsa kusuta pothana ndi zizolowezi zosokoneza bongo komanso malingaliro okhudzana ndi kusuta. Kuphatikiza apo, kuchita bwino kwa CBT kumafikira pakuletsa kristalo mu ma vapes a CBD, ndikupangitsa kuti ikhale njira yothandiza yowonetsetsa kuti CBD ili ndi mpweya wokwanira.
Ofufuza a Hemp akuwulula pang'onopang'ono kuthekera kwapadera kwa munthu wachichepere cannabinoids. Chimodzi mwazodabwitsa kwambiri ndi CBT (cannabicitran). Ngakhale sizimawonekera nthawi zonse mu chamba kapena kutsika kwambiri, kupita patsogolo kwatsopano mu sayansi ya cannabis kumapangitsa ofufuza kuti afufuze zomwe zingagwiritsidwe ntchito. Pakalipano, pali kafukufuku wochepa pa ubwino kapena cholinga cha CBT. Komabe, pamene makampani a cannabis akupitilira kukula ndikusintha, ndikofunikira kutsatira zomwe zapezedwa monga CBT, zomwe zitha kukupatsani mwayi watsopano wokhala ndi moyo wabwino komanso zinthu za ogula.
Cannabis, yomwe imadziwika kuti "chomera cha mamolekyu chikwi chimodzi", ili ndi mbiri yakale yopereka mwayi watsopano wopezeka. Ndi mwayi watsopano mu sayansi ya cannabis, zitha kukhala zotheka kuphatikiza ma cannabinoids osowa muzinthu zamankhwala ndi ogula. Mu bukhuli, muphunzira za momwe CBT ingagwiritsire ntchito. Pamene kafukufuku m'derali akupitilirabe, ndizosangalatsa kulingalira zatsopano zomwe tsogolo la CBT lingakhale nalo pamakampani a cannabis.
Kodi CBT Cannabinoid ndi chiyani?
Tisanalowe chifukwa chake CBT ndikofunikira, apa pali pang'ono mbiri. CBT idadzipatula koyamba kumapeto kwa zaka za m'ma 60s, koyambirira kwa 70s ndipo imapezeka kwambiri mu hemp kuposa chamba. Malinga ndi nkhani mu Matekinoloje a Cannabis, asayansi apeza mitundu isanu ndi inayi yosiyana pang'ono ya CBT, yomwe amakhulupirira kuti idapangidwa kuchokera CBDA. Iliyonse mwa ma CBT asanu ndi anayi ali ndi mamolekyu osiyana pang'ono.
Tsoka ilo, kafukufuku wochepa wa CBT hemp alipo. Choyamba, ndizosazolowereka, kotero ngakhale odziwa bwino za cannabis sadziwa za cannabinoid yonyalanyazidwa. Chachiwiri, sayansi ya cannabis ikupitilizabe kutsalira pakugwiritsa ntchito malonda mpaka kuvomerezedwa ndi boma. Dera la imvi limabweretsa zolepheretsa kuphunzira za cannabis ndipo zimabweretsa mantha azovuta zamalamulo pakati pa ofufuza. Pali maphunziro ochepa omwe alipo omwe amapereka chidziwitso chapamwamba pa CBT.
Chifukwa chiyani mumagwiritsa ntchito CBT? | | Ubwino wa CBT Cannabinoid
Zochepa zomwe zimadziwika za ubwino wa CBT pakadali pano, makamaka chifukwa chakuti pakhala pali maphunziro ochepa omwe achitika pa izo. Koma, tikuyamba kuwulula zidziwitso zochititsa chidwi.
Ngakhale kafukufuku wochepa pa CBT, wasonyeza kuthekera kopindulitsa mu maphunziro angapo. Kafukufuku woyamba, yemwe adachitika mu 2007, adapeza kuti CBT ili ndi zinthu zomwe zitha kulola kuti iwononge THC mudongosolo ndikuchepetsa kumverera "kwapamwamba" (Brogan et al.).
Kafukufuku wina, yemwe adachitika mu 2011, adapeza kuti adatha kupatula chinthu chofanana ndi CBT kuchokera ku chomera cha rhododendron. Chomerachi chakhala ndi mbiri yakale yogwiritsidwa ntchito muzamankhwala achi China, zomwe zimakhazikitsa njira yopititsira patsogolo kafukufuku wokhudzana ndi zopindulitsa za CBT (Iwata and Kitanaka). Zotsatira za phunziroli zikuwonetsa kufunika kofufuza ndi kugwiritsa ntchito zinthu zosadziwika bwino zopezeka mu chomera cha cannabis.
Ngati mukufuna kudziwa zomwe rhododendron imalimbikitsidwa, izi ndi zomwe White Rabbit Institute of Healing imanena kuti ndizogwiritsa ntchito.
Kafukufuku mu 1983 adafufuza ngati CBT ikhoza kuchepetsa kuthamanga kwa maso (Elsohly et al.). Ngakhale kafukufuku wochulukirapo akufunika, CBT ikuyenera kuthandizira pakupereka chithandizo chokulirapo chomwe chili ndi hemp, chifukwa cha zomwe zimatchedwa "entourage effect" pomwe cannabinoid iliyonse imawonjezera china chake pachomera ndikuwonjezera zotsatira za ena onse.
Anthu ena amafufuzanso mitundu ya maluwa a CBD omwe ali ndi CBT mkati mwawo pachifukwa ichi, ndipo pali manong'onong'ono kuti kupezeka kwa CBT kungapangitse zotsatira za CBD pazovuta zotsitsimula makamaka. Ndipo, momwe zimakhalira, CBT-C (yomwe ili yofanana ndi CBT) yakhala ikugwiritsidwa ntchito muzamankhwala achi China kwazaka masauzande ambiri kuti akhale wathanzi.
Kampani yotchedwa GVB Biopharma ikuyembekeza ngakhale kuthandizira kafukufuku wina ku CBT, chifukwa monga akunena, "Zinganenedwe kuti akatswiri a TCM akhala akugwiritsa ntchito CBT kwa zaka zambiri, kubwereketsa kuvomerezeka kwa kafukufuku wamakono wa CBT."
Ndipo chaka chathachi, kafukufuku watsopano adayang'ana ngati cannabitriol, yomwe imakhala yofanana ndi CBT, ingagwiritsidwe ntchito ngati mphamvu ya estrogen receptor agonist, zomwe zikutanthauza kuti zingathe kulimbikitsa bwino thupi lonse.Kikiwo et al.). Koma, tisanasangalale kwambiri, kufufuza kwina kumafunika kuti titsimikizire zomwe zapezazi. Chifukwa chake, khalani tcheru pamene tikuwulula zabwino zomwe cannabinoids wosadziwika bwino.
At Extract Labs, timamvetsetsa kufunikira kwa CBT ndipo taziphatikiza muzinthu zathu za CBD vape. Zonse Extract Labs Ma vape a CBD amapangidwa kuchokera zinthu za cannabis ndipo musamawonekere, kuwapanga kukhala osiyana ndi akasinja ena achilengedwe pamsika. Izi zidatheka chifukwa cha kuyesa kwamkati ndi gulu lathu la labotale, omwe ayesetsa kudzipatula ndikugwiritsa ntchito CBT moyenera.
CBT ikuyenera kuti ithandizire ku chithandizo chokulirapo chomwe chili ndi hemp, chifukwa cannabinoid iliyonse imawonjezera china chake pachomera ndikuwonjezera zotsatira za ena onse.
Zotsatira za CBT Cannabinoid
Kupatula kuletsa mwachilengedwe kuwunikira komanso kukhala ndi zotsatira zofanana ndi za CBD ndi CBG, kafukufuku wocheperako womwe ulipo ukuwonetsa kuti CBT ikhoza kukhala ndi zotsatira zina.
Mu kafukufuku wa 2007 pa THCMakhalidwe oledzera, ofufuza adapeza kuti CBT imachita zofanana ndi CBD mu kuthekera kwake kuchepetsa zotsatira za psychoactive THC, malinga ndi tsamba la mbiri ya cannabis Maphunziro 58.
Komanso, CBT ikuwoneka kuti imabweretsa zotsatira zosaoneka bwino za CBD, yomwe imadziwika chifukwa cha kupumula kwake, ndi CBG, yodziwika chifukwa cha kuthekera kwake polimbikitsa kukhazikika ndi kuyang'ana. Popeza CBT imakhalabe gawo losawoneka bwino komanso losagwiritsidwa ntchito bwino la hemp, umboni wokwanira wokwanira ulibe, zomwe zimatisiya ndi kumvetsetsa kosakwanira momwe zingakhudzire anthu mwapadera.
CBT vs CBD
Pakadali pano, sizothandiza kuyerekeza CBT ndi CBD. Sitikudziwa mokwanira za CBT panobe. Koma apa pali kuwonongeka kwachidule kwa CBT ndi CBD zofanana ndi zosiyana.
- CBD ndi CBT si psychoactive
- CBD ndipo CBT ikhoza kufooketsa zotsatira za psychoactive THC
- CBD cannabinoid imapanga mawonekedwe
- CBT ikhoza kupewa CBD mafuta a vape kuchokera ku kristalo
CBT vs CBN
Kusiyana kwakukulu kumodzi ndiko CBN ndi kuwonongeka kwa THC, kutanthauza kuti amapangidwa pamene THC imakhudzidwa ndi kutentha, kuwala, kapena mpweya. Kumbali ina, CBT ndi mankhwala achilengedwe omwe amapezeka mu chomera cha cannabis, koma amapezeka m'malo otsika kwambiri poyerekeza ndi ma cannabinoids ena. THC ndi CBD.
Kusiyana kwina ndiko CBN Amaganiziridwa kuti ali ndi zinthu zokhazika mtima pansi ndipo zingakhale zothandiza kulimbikitsa kugona. Kafukufuku wasonyeza zimenezo CBN akhoza kuwonjezera kupuma. CBT, kumbali ina, ikhoza kukhala ndi zovuta komanso zochepetsera zowawa, koma kafukufuku wochulukirapo akufunika kuti amvetsetse bwino mapindu ake ochiritsira.
CBN amadziwikanso kuti ali ndi chiyanjano CB2 zolandilira, zomwe zimapezeka m'thupi lonse ndikuwongolera zowawa, kutupa, ndi chitetezo chamthupi. CBT, komabe, imatha kuyanjana ndi dongosolo la endocannabinoid pomanga CB1 ndi CB2 zovomerezeka.
CBT vs CBC
ngati CBD ndi CBN, Ndondomekoyi Amaganiziridwa kuti amalumikizana ndi dongosolo la endocannabinoid pomanga ndi CB1 ndi CB2 ma receptor. Ilinso ndi mgwirizano wa TRPV1 ma receptor, omwe amakhudzidwa ndikuwona kupweteka, kutentha, ndi kutupa. CBT, kumbali ina, ikhoza kuyanjananso ndi dongosolo la endocannabinoid pomangirira ku CB1 ndi CB2 zolandilira, koma kufufuza kwina kumafunika kuti timvetsetse njira zenizeni za momwe zimagwirizanirana ndi dongosolo la endocannabinoid.
CBT vs THC
CBT ndi THC onsewo ndi mankhwala omwe amapezeka mu chomera cha cannabis, koma amakhala ndi zotsatira zosiyana pathupi ndi malingaliro.
Kusiyana kwakukulu ndikuti CBT imapezeka m'malo otsika kwambiri muzomera za cannabis poyerekeza ndi THC. Izi zikutanthawuza kuti ndizochepa kuti zipezeke muzinthu zambiri zokwanira kuti zikhale ndi mphamvu zambiri pa thupi kapena maganizo. THCKomano, imapezeka m'magulu okwera kwambiri ndipo imatengedwa kuti ndi gawo lalikulu la chamba.
Zotsatira za CBT sizinaphunziridwe bwino ndipo sizidziwika zambiri za zotsatira zake za psychoactive. THC, Komano, ndilo gawo loyamba la psychoactive mu cannabis ndipo amadziwika kuti amapanga "mkulu" wokhudzana ndi kugwiritsa ntchito chamba.
Kafukufuku wina adafufuza ngati CBT ili ndi mphamvu zochepetsera kupsinjika, zomwe zingapangitse kuti zikhale zothandiza pochiza kusapeza bwino ndi kuwawa. Kafukufuku wina adayang'ana ngati CBT ikhoza kukhala ndi zinthu zochepetsera, zomwe zingakhale zothandiza kulimbikitsa kugona.
CBT imathanso kukhudza dongosolo la endocannabinoid. Dongosolo la endocannabinoid ndi njira yovuta yowonetsera ma cell yomwe imathandizira kuwongolera machitidwe osiyanasiyana amthupi, monga kuwawa, kukhumudwa, komanso chidwi.
CBT ikhoza kuyanjana ndi dongosolo la endocannabinoid pomanga ma CB1 ndi CB2 receptors, omwe amapezeka muubongo ndi thupi lonse. Komabe, kafukufuku wochulukirapo akufunika kuti amvetsetse njira zenizeni za momwe CBT imalumikizirana ndi dongosolo la endocannabinoid.
Kodi CBT Ndi Yovomerezeka?
Inde, CBT ndiyovomerezeka pansi pa 2018 Farm Bill Act. Malingana ngati malondawo alibe opitilira 0.3% ya THC, ndizovomerezeka.
CBT imathanso kukhudza dongosolo la endocannabinoid. Dongosolo la endocannabinoid ndi njira yovuta yowonetsera ma cell yomwe imathandizira kuwongolera machitidwe osiyanasiyana amthupi, monga kuwawa, kukhumudwa, komanso chidwi.
Tsogolo la Cannabinoids Yaing'ono
Cannabicitran (CBT) ndi cannabinoid osowa mumsika wa hemp omwe akuyang'ana chidwi ndi zotsatira zake zosaledzeretsa zomwe zingafanane ndi CBD ndi CBG komanso mapindu omwe angakhale abwino. Ngakhale kusowa kwa kafukufuku, kafukufuku woyambirira akuwonetsa kuti CBT ikhoza kupititsa patsogolo zotsatira za ma cannabinoids ena, zomwe zimathandizira kuti pakhale thanzi labwino. Pamene makampani akukula, zidzakhala zosangalatsa kuona momwe CBT ikulowera mu chithunzi chachikulu cha hemp ndi ntchito zake zomwe zingatheke. Pakadali pano, chidwi chachikulu chimayang'ana pa CBD ndi THC, koma momwe kumvetsetsa kwathu kuyanjana kwazinthuzi ndi thupi kukukulirakulira, kuyang'ana kudzasunthira kuzinthu zina zazing'ono 120 zomwe sizikudziwika.
Extract Labs ili m'mphepete mwa kuchotsa ndi kukonza ma cannabinoids ang'onoang'ono. Ndife okondwa kuwona zomwe maphunziro aziwululira za kuthekera kwa chomera cha cannabis kukhudza miyoyo ya anthu ndikutha kupatsa ogula zinthu zoyera, zachilungamo komanso zotsika mtengo kuti aliyense awone zomwe angawachitire!
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Ntchito Zosimbidwa
Brogan, Andrew P., et al. "Antibody-catalyzed oxidation ya delta (9) -tetrahydrocannabinol." PubMed, 28 Marichi 2007, https://pubmed.ncbi.nlm.nih.gov/17335216/. Adafikira pa 25 Januware 2023.
Elsohly, Mahmoud A., et al. "Cannabinoids mu glaucoma II: Zotsatira za cannabinoids osiyanasiyana pa kukakamiza kwa intraocular kwa kalulu." Taylor & Francis Online, 2009, https://www.tandfonline.com/doi/abs/10.3109/02713688409000797. Adafikira pa 26 Januware 2023.
Iwata, Naoki, and Susumu Kitanaka. "Zatsopano za cannabinoid ngati chromane ndi chromene zochokera ku Rhododendron anthopogonoides." PubMed, 2011, https://pubmed.ncbi.nlm.nih.gov/22041081/. Adafikira pa 25 Januware 2023.
Kikiowo, Babtomiwa, et al. "Induced Fit Docking and Automated QSAR Studies Awulula ER-a Inhibitory Activity of Cannabis Sativa in Breast Cancer." Eureka Select, 10 Ogasiti 2021, https://www.eurekaselect.com/article/113837. Adafikira pa 26 Januware 2023.
